ABOUT US

The Division of Hemostasis and Thrombosis is located in the Center for Life Sciences in Boston’s Longwood Medical Area, a vibrant center for patient care and biomedical  research.

Mission

Our mission is to innovate in the basic, translational, and clinical science of hemostatic and thrombotic disorders while training the next generation of leaders in the field.

History of the Division

The Center for Hemostasis and Thrombosis Research was founded in 1975 at Tufts University School of Medicine and New England Medical Center by Drs. Bruce and Barbara C. Furie. This laboratory has been committed to an interdisciplinary approach to the study of blood coagulation, platelet and vascular biology. The Center moved in late 1997 to its current location at Harvard Medical School within the Beth Israel Deaconess Medical Center, becoming the Division of Hemostasis and Thrombosis in late 2000. The Center has a long training history in the field of blood coagulation and vascular biology; over 100 postdoctoral and predoctoral trainees have been engaged in research in the Center.  The result has been hundreds of publications that include many landmark papers and a much-deserved international reputation and leadership role for the Center.  In 2017, Dr. Robert Flaumenhaft was appointed Chair of the Division of Hemostasis and Thrombosis.

Facilities/Resources

The Division of Hemostasis and Thrombosis at Beth Israel Deaconess Medical Center (BIDMC) is located on the 9th floor of the Center for Life Sciences (CLS), a state-of-the-art research facility in the Longwood Medical Area. The division contains 8,000 net square feet of offices, laboratories, and equipment.  Laboratory facilities for the Division include a shared equipment room, cold room, instrument room, and several facilities dedicated to specific tasks including coagulometry and platelet aggregometry, tissue culture, molecular biology, protein purification, and small animal surgery.  In addition, the Division maintains a unique intravital microscopy core facility (widefield and confocal) that continues to pioneer new rodent models of hemostasis and thrombosis.  Beyond these resources, the BIDMC and Harvard Medical School maintain an extraordinary variety of expert core facilities in areas ranging from flow cytometry to proteomics to genome engineering and transgenic animal development.

Beth Israel Deaconess Medical Center

The Beth Israel Deaconess Medical Center (BIDMC) is a biomedical research institution and a major teaching hospital of Harvard Medical School.   BIDMC derives over $130 million per year from extramural sources, including over $80 million per year from the NIH, for its research programs.  Given the adjacency of the Beth Israel Deaconess Medical Center to Harvard Medical School, Brigham & Women’s Hospital, the Dana Farber Cancer Institute and Children’s Hospital, the critical mass of outstanding biomedical research in a single location is a great advantage of this program.  

 

Landmark Papers

Mechanism of Factor X Deficiency in Amyloidosis

(NEJM 1977)

Discovery of P-selectin

(Cell 1989)

The Role of PDI in Thrombus Formation

(JCI 2008)

     

Review of the Molecular Basis of Coagulation

(Cell 1988)

Real-time in vivo Imaging of Thrombus Formation

(Nature Medicine 2002)

PDI Inhibition as an Antithrombotic Strategy

(JCI 2012)