Bruce Furie, MD

Professor of Medicine
Harvard Medical School
Division of Hemostasis and Thrombosis
Beth Israel Deaconess Medical Center

330 Brookline Avenue, Boston MA 02215
Tel: 617-735-4002 FAX: 617-735-4000
bfurie@bidmc.harvard.edu

Bio

Dr. Bruce Furie is a Professor of Medicine at Harvard Medical School and Chief of the Division of Hemostasis and Thrombosis. Dr. Furie received his AB from Princeton University and his MD from the University of Pennsylvania. After residency at the Hospital of the University of Pennsylvania, he was a postdoctoral fellow at the National Institutes of Health in the laboratory of Drs. Christian B. Anfinsen and Alan N. Schechter. After clinical hematology training, he, in collaboration with Dr. Barbara C. Furie, established their joint laboratory at New England Medical Center and Tufts University School of Medicine in 1975; he became Chief of the Division of Hematology-Oncology from 1990 to 1996. Upon moving to the Beth Israel Deaconess Medical Center, he was Director of the Beth Israel Deaconess Cancer Center from 1997 until 2000. Dr. Furie’s research interests focus within the area of hemostasis and thrombosis. Major activities in the laboratory involve the study of the structure-function relationships of the blood coagulation proteins, with special attention directed toward the vitamin K-dependent proteins, and the assembly of Factor IX and Factor VIII on membrane surfaces. The structural biology of blood coagulation proteins, including Factor VIII, have been of special interest.  In addition, this laboratory discovered P-selectin, and the study of vascular cell adhesion molecules has been a central theme of the laboratory. This group developed novel instrumentation for real time in vivo confocal and widefield imaging of thrombus formation in the microcirculation of a live mouse.  Using these techniques, they study the pathophysiology of thrombosis and have established a critical role for extracellular protein disulfide isomerase in this process.

Dr. Bruce Furie was the recipient of the William Dameshek Prize of the American Society of Hematology in 1984, a MERIT Award from the NIH, an honorary degree from Lund University (Sweden) in 2003. More recently, he received a Distinguished Scientist Award by the American Heart Association in 2014, the E. Darnall Thomas Lecture and Prize from the American Society of Hematology in 2015 and the Princeton University Class of 1966 Locomotive Award in 2017.  Dr. Furie was a co-editor of the hematology textbook, HEMATOLOGY: BASIC PRINCIPLES AND PRACTICE and lead editor of CLINICAL HEMATOLOGY-ONCOLOGY: PRESENTATIONS, DIAGNOSIS AND TREATMENT. He served as the President of the 2009 Congress of the International Society on Thrombosis and Haemostasis, and has served on the editorial boards of BLOOD, the Journal of Thrombosis and Haemostasis, and MOLECULAR MEDICINE and was the Secretary General of the International Society on Thrombosis and Haemostasis.

Current and Recent Grants

R01HL136394 (PI, Furie)
NIH/NHLBI
Vascular Thiol Isomerases in Thrombosis
Role: Principal Investigator

R13HL134226 (PI, Furie)
NIH/NHLBI
FASEB SRC on Functional Disulfide Bonds in Health and Disease
Role: Principal Investigator

U54HL112302 (PI, Furie)
NIH/NHLBI
Protein disulfide isomerases: A new class of antithrombotic targets
Role: Principal Investigator