Pavan K. Bendapudi, MD

Assistant Professor of Medicine
Harvard Medical School
Division of Hemostasis and Thrombosis
Beth Israel Deaconess Medical Center

3 Blackfan Circle, Room 906, Boston MA 02215
Tel: 617-735-4252 FAX:617-735-4000
pkbendapudi@partners.org

Bio

Dr. Bendapudi completed his undergraduate degree in biochemistry at Harvard College  and received his medical degree from Stanford University, where he was a Howard Hughes Medical Institute research fellow in the laboratory of Dr. Dean Felsher.  He subsequently pursued training in internal medicine at Massachusetts General Hospital, followed by fellowships in hematology, medical oncology, and transfusion medicine.  Dr. Bendapudi continues to be clinically active in both hematology and transfusion medicine.  He first joined the Division of Hemostasis and Thrombosis as a postdoctoral fellow in Dr. Flaumenhaft’s laboratory. Dr. Bendapudi holds academic appointments at both Beth Israel Deaconess Medical Center and Massachusetts General Hospital.

Dr. Bendapudi’s laboratory is focused on the biology of humoral coagulation factors and takes a translational approach to studying the mechanism underlying hemostatic and thrombotic disease as it pertains to patient care.  The central project in his laboratory is focused on the mechanism by which factor 12 (FXII) participates in coagulation, with an emphasis on the recruitment, activation, and propagation of FXII at sites of vascular injury and thrombus formation.

In addition to his basic research, Dr. Bendapudi serves as co-principal investigator of the Harvard Thrombotic Microangiopathies Research Collaborative, an interdisciplinary, multi-institutional project to study Thrombotic Thrombocytopenic Purpura (TTP) and allied disorders.  His group has described one of the world’s largest experiences in TTP and reported the PLASMIC clinical prediction tool for the bedside diagnosis of TTP.

Current and Recent Grants

Broad Institute/Bayer HealthCare CVD Collaboration (PI, Bendapudi)                                                            
“Targeting Factor XII in Thrombosis and Hemostasis.” (Beth Israel Deaconess Medical Center). 
The goal of this project is to identify methods to screen for small molecule inhibitors of factor XII and to validate novel indications for factor XII inhibition.

NIH 1K08 HL136840-01 (PI, Bendapudi)                                                                                                                                                                        
Mentored Clinical Scientist Research Career Development Award (Beth Israel Deaconess Medical Center/Harvard Medical School).
“The Role of Coagulation Factor XII in Hemostasis and Thrombosis.” 
The goal of this project is to understand the mechanisms by which factor XII is recruited, activated, and propagated at sites of thrombus formation.

NIH U54 HL112302-03 (PI, Furie)                                                                                                                                                                          
NHLBI Thrombosis-Hemostasis Scholar (Beth Israel Deaconess Medical Center/Harvard Medical School). “Identification and Characterization of Novel Antithrombotic PDI Inhibitors.”

National Hemophilia Foundation (PI, Bendapudi)                                 
NHF-Baxter Clinical Fellowship (Boston Hemophilia Center).

Hemostasis and Thrombosis Research Society (PI, Bendapudi)                     
Mentored Research Award (Beth Israel Deaconess Medical Center/Harvard Medical School).  “Antithrombotic Mechanisms of Protein Disulfide Isomerase Inhibition in vivo.”