Pavan K. (Tem) Bendapudi, MD

Assistant Professor of Medicine
Harvard Medical School
Division of Hemostasis and Thrombosis
Beth Israel Deaconess Medical Center

3 Blackfan Circle, Room 906, Boston MA 02215
Tel: 617-735-4252 FAX:617-735-4000
pkbendapudi@partners.org

Bio

 Dr. Bendapudi completed his undergraduate degree in biochemistry at Harvard College and received his medical degree from Stanford University, where he was a Howard Hughes Medical Institute research fellow in the laboratory of Dr. Dean Felsher. He subsequently pursued training in internal medicine at Massachusetts General Hospital, followed by fellowships in hematology, medical oncology, and transfusion medicine. Dr. Bendapudi continues to be clinically active in both hematology and transfusion medicine. He first joined the Division of Hemostasis and Thrombosis as a postdoctoral fellow in Dr. Flaumenhaft’s laboratory. Dr. Bendapudi holds academic appointments at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and the Broad Institute of Harvard and MIT.

Research

Dr. Bendapudi’s laboratory is focused on the biology of humoral coagulation factors and takes a translational approach to studying the mechanism underlying hemostatic and thrombotic disease as it pertains to patient care. A central project in his laboratory is focused on the mechanism by which factor 12 (FXII) participates in coagulation, with an emphasis on the recruitment, activation, and propagation of FXII at sites of vascular injury and thrombus formation.

Dr. Bendapudi’s group also studies the functional genomics of purpura fulminans (PF), a rare, highly thrombotic subtype of disseminated intravascular coagulation seen in patients with sepsis. Whole exome sequencing of PF patients by Dr. Bendapudi’s group has implicated rare, inherited defects of the complement system in the development of PF and sepsis coagulopathy. Ongoing studies are focused on the genetic risk stratification of patients with sepsis and the development of drugs to target dysregulated innate immunity.

In addition to his basic research, Dr. Bendapudi serves as co-principal investigator of the Harvard Thrombotic Microangiopathies Research Collaborative, an interdisciplinary, multi-institutional project to study Thrombotic Thrombocytopenic Purpura (TTP) and allied disorders. His group has described one of the world’s largest experiences in TTP and developed the PLASMIC clinical prediction tool for rapid diagnosis of TTP.