Pavan K. (Tem) Bendapudi, MD

Assistant Professor of Medicine
Harvard Medical School
Division of Hemostasis and Thrombosis
Beth Israel Deaconess Medical Center

3 Blackfan Circle, Room 906, Boston MA 02215
Tel: 617-735-4252 FAX:617-735-4000
pkbendapudi@partners.org

Bio

Dr. Bendapudi completed his undergraduate degree in biochemistry at Harvard College and received his medical degree from Stanford University, where he was a Howard Hughes Medical Institute research fellow in the laboratory of Dr. Dean Felsher. He subsequently pursued training in internal medicine at Massachusetts General Hospital, followed by fellowships in hematology, medical oncology, and transfusion medicine. Dr. Bendapudi continues to be clinically active in both hematology and transfusion medicine. He first joined the Division of Hemostasis and Thrombosis as a postdoctoral fellow in Dr. Flaumenhaft’s laboratory. Dr. Bendapudi is currently Assistant Professor of Medicine at Harvard Medical School and holds academic appointments at Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and the Broad Institute of Harvard and MIT.

 

Research

Dr. Bendapudi’s laboratory is focused on the biology of humoral coagulation factors and takes a translational approach to studying the mechanism underlying hemostatic and thrombotic disease as it pertains to patient care. A central project in his laboratory is focused on the mechanism by which factor 12 (FXII) participates in coagulation, with an emphasis on the recruitment, activation, and propagation of FXII at sites of vascular injury and thrombus formation.

Dr. Bendapudi also has a strong interest in the functional genomics of bleeding and clotting disorders.  His group has assembled whole exome sequencing cohorts in purpura fulminans (PF) and immune thrombotic thrombocytopenic purpura (iTTP), two rare and catastrophic thrombotic conditions.  At the other extreme of scale, through work being performed in collaboration with the Broad Institute, members of the Bendapudi lab are leveraging large genotyping and next-gen sequencing datasets such as the UK Biobank and NIH All of Us to answer fundamental questions about thrombosis and bleeding. 

In addition to his basic research, Dr. Bendapudi serves as co-principal investigator of the Harvard Thrombotic Microangiopathies Research Collaborative, an interdisciplinary, multi-institutional project to study Thrombotic Thrombocytopenic Purpura (TTP) and allied disorders. His group has described one of the world’s largest experiences in TTP and developed the PLASMIC clinical prediction tool for rapid diagnosis of TTP.

Current and Recent Grants

 

1R01HL166246 (PI, Bendapudi)                                                                                                        
“Coagulation Factor XII Recruitment and Activation During Thrombus Formation.”

CSL Behring Norbert Heimburger Award for Coagulation Research (PI, Bendapudi)

“Coagulation fator XII is Activated via Noncanonical Binding to Platelet Integrin αIIbβ3.”

NIH 1R03 HL162761 (PI, Bendapudi)                                                                                                        
“Mechanisms of Coagulation Factor XII Recruitment and Activation at the Platelet Surface.”

NIH 1R21 HL153655 (PI, Bendapudi)                                                                                                        
“Elucidating the Role of Inherited Complement System Defects in the Molecular Pathophysiology of Sepsis and Purpura Fulminans.”

Broad Institute/Novo Ventures Greenhouse Collaborative (PI, Bendapudi)                                                            
“Targeting Factor XII in Thrombosis and Hemostasis.”

NIH 1K08 HL13684001 (PI, Bendapudi)                                                          
“The Role of Coagulation Factor XII in Hemostasis and Thrombosis.”