Robert Flaumenhaft, MD, PhD

Professor of Medicine
Harvard Medical School
Division of Hemostasis and Thrombosis
Beth Israel Deaconess Medical Center

3 Blackfan Circle, Room 905, Boston MA 02215
Tel: 617-735-4005 FAX: 617 735-4000


Dr. Flaumenhaft received his M.D. and Ph.D. from NYU School of Medicine, completed a fellowship in Hematology/Oncology at Beth Israel Deaconess Medical Center, and received a M.M.Sc. from Harvard Medical School. He is currently a Professor at Harvard Medical School. His laboratory within the Division of Hemostasis and Thrombosis at BIDMC focuses on platelet biology and mechanisms of thrombus formation. He also cares for patients with bleeding or clotting disorders. Dr. Flaumenhaft is director of the T32 training program entitled, “Program in Blood Coagulation and Vascular Biology” and associate director of the Translational Research Center in Thrombosis and Hemostasis. He is a section editor for Thrombosis and Haemostasis and serves on the editorial boards of Blood, JCI Insight, JTH, Thrombosis Research, and Seminars in Thrombosis and Hemostasis. He is a standing member of the Hemostasis and Thrombosis NIH Study Section and has served as conference organizer and on scientific subcommittees for several scientific meetings. His work in platelet biology and thrombotic mechanisms has earned him a Career Award from the Burroughs Wellcome Fund, a Junior Faculty Award from the American Society of Hematology, and an Established Investigator Award from the American Heart Association. He was elected to the American Society for Clinical Investigation.

Current and Recent Grants

1R35HL135775-01 (PI, Flaumenhaft)                                              
Thiol Isomerases in Hemostasis and Thrombosis                 
The goal of this project is to evaluate the role of thiol isomerases in hemostasis and thrombosis in health and disease. The studies will include in vitro studies, animal models of thrombotic disease, and human studies all focused around the common goal of understanding how thiol isomerase contribution to bleeding and clotting.

5R01HL125275-03 (PI, Flaumenhaft)                                   
Targeting endothelium in sepsis
This project will study protective signaling mechanisms in sepsis and evaluate the efficacy of activating cytoprotective signaling in the setting of sepsis. The mechanisms underlying thrombosis of sepsis will be studied. In addition, an endothelial barrier function assay will be used as a new method to monitor progression and direct therapy in sepsis.

5T32HL007917-18 (PI, Flaumenhaft)                                                           
Program in Blood Coagulation and Vascular Biology
This is a training grant. Learn more.

4U54HL112302-05 (Leader, Project 2)                                             
Protein disulfide isomerases: A new class of antithrombotic targets
High throughput screening to identify potent and selective inhibitors of PDI are performed. 

5R01GM115417-02    (subcontract; PI, Whitman)                                        
NIH/NIGMS/Harvard Medical School                                               
The first secreted Tyrosine kinase
The goal of this subcontract is to support studies that will evaluate the role of platelet VLK thrombus formation in vivo.