Recent Publications

Flaumenhaft Lab

1. Chinnaraj M, Flaumenhaft R, Pozzi N. Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles. J Biol Chem. 2022. doi: 10.1016/j.jbc.2022.102217.

2. Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood. 2022. doi: 10.1182/blood.2021012250.

3. Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA. PIEZO1 mediates a mechanothrombotic pathway in diabetes. Sci Transl Med. 2022;14(626):eabk1707. doi: 10.1126/scitranslmed.abk1707.

4. Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu XG; MGH COVID-19 Collection and Processing Team, Peters KG, Flaumenhaft R, Parikh SM. Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19. JCI Insight. 2021;6(20):e151527. doi: 10.1172/jci.insight.151527.

5. Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R. The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation. Blood. 2022;139(1):104-117. doi: 10.1182/blood.2020010342.

6. Italiano JE, Bender M, Merrill-Skoloff G, Ghevaert C, Nieswandt B, Flaumenhaft R. Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes. Blood. 2021;138(20):1998-2001. doi: 10.1182/blood.2021012496.

7. Sharda AV, Bogue T, Barr A, Mendez LM, Flaumenhaft R, Zwicker JI. Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms. Clin Cancer Res. 2021;27(20):5708-5717. doi: 10.1158/1078-0432.CCR-21-1140.

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Furie Lab

1. Bury L, Megy K, Stephens JC, Grassi L, Greene D, Gleadall N, Althaus K, Allsup D, Bariana TK, Bonduel M, Butta NV, Collins P, Curry N, Deevi SVV, Downes K, Duarte D, Elliot K, Falcinelli E, Furie B, et al. Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants. Hum Mutat. 2020;41(1):277‐290. doi:10.1002/humu.23927

2. Eriksson O, Chiu J, Hogg PJ, Atkinson JP, Liszewski MK, Flaumenhaft R, Furie B. Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation. J Biol Chem. 2019;294(13):4878‐4888. doi:10.1074/jbc.RA118.006792

3. Eriksson O, Stopa J, Furie B. Identification of PDI Substrates by Mechanism-Based Kinetic Trapping. Methods Mol Biol. 2019;1967:165‐182. doi:10.1007/978-1-4939-9187-7_10

4. Sharda A, Furie B. Regulatory role of thiol isomerases in thrombus formation. Expert Rev Hematol. 2018;11(5):437‐448. doi:10.1080/17474086.2018.1452612

5. Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z, Yao L, Furie B, Huang Mingdong. A long-acting PAI-1 inhibitor reduces thrombus formation. Thromb Haemost. 2017;117(7):1338‐1347. doi:10.1160/TH16-11-0891

6. Stopa JD, Baker KM, Grover SP, Flaumenhaft R, Furie B. Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates. J Biol Chem. 2017;292(22):9063‐9074. doi:10.1074/jbc.M116.771832

7. Bowley SR, Fang C, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation. Nat Commun. 2017;8:14151. Published 2017 Feb 20. doi:10.1038/ncomms14151

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Bauer Lab

1. Darzi AJ, Repp AB, Spencer FA, Morsi RZ, Charide R, Etxeandia-Ikobaltzeta I, Bauer KA, et al. Risk-assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews. Blood Adv. 2020;4(19):4929-4944. doi:10.1182/bloodadvances.2020002482

2. Patell R, Bogue T, Koshy A, Bindal P, Merrill M, Aird WC, Bauer KA, Zwicker JI. Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020;136(11):1342-1346. doi:10.1182/blood.2020007938

3. Patell R, Bogue T, Bindal P, Koshy A, Merrill M, Aird WC, Bauer KA, Zwicker JI. Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19. J Thromb Haemost. 2020;18: 2349– 2357. doi:10.1111/jth.15018

4. Patell R, Khan AM, Bogue T, Merrill M, Koshy A, Bindal P, Joyce R, Aird WC, Neuberg D, Bauer KA, Zwicker JI. Heparin induced thrombocytopenia antibodies in Covid-19. Am J Hematol. 2020;95: E295-E296. doi:10.1002/ajh.25935

5. Neumann I, Izcovich A, Zhang Y, Rada G, Kahn SR, Spencer F, Rezenda S, Dentali F, Bauer K, et al. DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta-analysis that informed 2018 ASH guidelines. Blood Adv. 2020;4(7):1512‐1517. doi:10.1182/bloodadvances.2019000840

6. Yang S, Bauer KA, Singleton JM, Papavassiliou E, Kramer DB. A Balancing Act. Circulation. 2020;141(13):1103‐1106. doi:10.1161/CIRCULATIONAHA.119.044780

7. Moran J, Bauer KA. Managing thromboembolic risk in patients with hereditary and acquired thrombophilias. Blood. 2020;135(5):344‐350. doi:10.1182/blood.2019000917

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Zwicker Lab

1. Chiasakul T, Patell R, Maraveyas A, Carrier M, Zwicker JI. Discordant reporting of VTE in pancreatic cancer: A systematic review and meta-analysis of thromboprophylaxis versus chemotherapeutic trials [published online ahead of print, 2020 Nov 10]. J Thromb Haemost. 2020;10.1111/jth.15175. doi:10.1111/jth.15175

2. Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, Moro FM, Razanamahery J, Riches JC, Zwicker JI, et al. Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients [published online ahead of print, 2020 Oct 28]. Blood. 2020;blood.2020008824. doi:10.1182/blood.2020008824

3. How J, Leiva O, Bogue T, Fell GG, Bustoros MW, Connell MT, Connors JM, Ghobrial IM, Kuter DJ, Mullally A, Neuberg D, Zwicker JI, et al. Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020;98:106459. doi:10.1016/j.leukres.2020.106459

4. Patell R, Bogue T, Koshy A, Bindal P, Merrill M, Aird WC, Bauer KA, Zwicker JI. Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020;136(11):1342-1346. doi:10.1182/blood.2020007938

5. Patell R, Bogue T, Bindal P, Koshy A, Merrill M, Aird WC, Bauer KA, Zwicker JI. Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19 [published online ahead of print, 2020 Jul 21]. J Thromb Haemost. 2020;10.1111/jth.15018. doi:10.1111/jth.15018

6. Patell R, Khan AM, Bogue T, Merrill M, Koshy A, Bindal P, Joyce R, Aird WC, Neuberg D, Bauer KA, Zwicker JI. Heparin induced thrombocytopenia antibodies in Covid-19 [published online ahead of print, 2020 Jul 13]. Am J Hematol. 2020;10.1002/ajh.25935. doi:10.1002/ajh.25935

7. Patell R, Zwicker JI. Inpatient prophylaxis in cancer patients: where is the evidence?. Thromb Res. 2020;191 Suppl 1:S85-S90. doi:10.1016/S0049-3848(20)30403-5

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Bendapudi Lab

1. Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, Goodarzi K, Bendapudi PK, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136(4):489-500. doi:10.1182/blood.2020006520

2. Chaudhry SA, Serrata M, Tomczak L, Higgins S, Ryu J, Laprise D, Enjyoji K, Bekendam R, Kaushik V, Flaumenhaft R, Bendapudi PK. Cationic Zinc is Required for Factor XII Recruitment and Activation by Stimulated Platelets and for Thrombus Formation in vivo [published online ahead of print, 2020 Jun 16]. J Thromb Haemost. 2020;10.1111/jth.14964. doi:10.1111/jth.14964

3. Colling M, Sun L, Upadhyay V, Ryu J, Li A, Uhl L, Kaufman RM, Stowell CP, Dzik WH, Makar RS, Bendapudi PK. Deaths and complications associated with the management of acute immune thrombotic thrombocytopenic purpura. Transfusion. 2020;60(4):841‐846. doi:10.1111/trf.15721

4. Upadhyay VA, Geisler BP, Sun L, Uhl L, Kaufman RM, Stowell C, Makar RS, Bendapudi PK. Utilizing a PLASMIC score-based approach in the management of suspected immune thrombotic thrombocytopenic purpura: a cost minimization analysis within the Harvard TMA Research Collaborative. Br J Haematol. 2019;186(3):490‐498. doi:10.1111/bjh.15932

5. Sun L, Mack J, Li A, Ryu J, Upadhyay VA, Uhl L, Kaufman RM, Stowell CP, Dzik WS, Makar RS, Bendapudi PK. Predictors of relapse and efficacy of rituximab in immune thrombotic thrombocytopenic purpura. Blood Adv. 2019;3(9):1512‐1518. doi:10.1182/bloodadvances.2019031039

6. Bendapudi PK, Robbins A, LeBoeuf N, et al. Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate. Blood Adv. 2018;2(21):2917‐2921. doi:10.1182/bloodadvances.2018024430

7. Fitzsimons MG, Leaf RK, Mack J, Bendapudi PK, Shen T, Cameron DE. Perioperative management of a redo aortic root replacement in a patient with severe factor XI deficiency. J Card Surg. 2018;33(2):86‐89. doi:10.1111/jocs.13526

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Schulman Lab

1. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. TMEM16E regulates endothelial cell procoagulant activity and thrombosis. J Clin Invest. 2023 Mar 23:e163808. doi: 10.1172/JCI163808. Epub ahead of print.

2. Schulman S. How the tissue factor-VIIa complex keeps two substrates in the loop. J Thromb Haemost. 2021;19(1):52-54. doi: 10.1111/jth.15148.

3. Schulman S, El-Darzi E, Florido MH, Friesen M, Merrill-Skoloff G, Brake MA, Schuster CR, Lin L, Westrick RJ, Cowan CA, Flaumenhaft R, NIHR BioResource, Ouwehand WH, Peerlinck K, Freson K, Turro E, Furie B. A coagulation defect arising from heterozygous premature termination of tissue factor. J Clin Invest. 2020;130(10):5302-5312. doi:10.1172/JCI133780

4. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018;128(4):1471‐1484. doi:10.1172/JCI97488

5. Stolla M, Chang S, Schulman S, Bauer K, Haspel R, Lerner AB. Use of thromboelastography in the management of a patient with acquired von Willebrand disease undergoing cardiac bypass surgery. Br J Haematol. 2018;181(1):143‐145. doi:10.1111/bjh.14511

6. Simeoni I, Stephens JC, Hu F, Deevi SVV, Megy K, Bariana TK, Lentaigne C, Schulman S, et al. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood. 2016;127(23):2791‐2803. doi:10.1182/blood-2015-12-688267

7. Turro E, Greene D, Wijgaerts A, et al. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Sci Transl Med. 2016;8(328):328ra30. doi:10.1126/scitranslmed.aad7666

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Sharda Lab

1. Sharda AV, Barr AM, Harrison JA, Wilkie AR, Fang C, Mendez LM, Ghiran IC, Italiano JE, Flaumenhaft R. vWF maturation and release are controlled by two regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2 [published online ahead of print, 2020 Jul 2]. Blood. 2020;blood.2020005300. doi:10.1182/blood.2020005300

2. Zwicker JI, Roopkumar J, Puligandla M, Schlechter BL, Sharda AV, Peereboom D, Joyce R, Bockorny B, Neuberg D, Bauer KA, Khorana AA. Dose-adjusted enoxaparin thromboprophylaxis in hospitalized cancer patients: a randomized, double-blinded multicenter phase 2 trial. Blood Adv. 2020;4(10):2254-2260. doi:10.1182/bloodadvances.2020001804

3. Sharda A, Furie B. Regulatory role of thiol isomerases in thrombus formation. Expert Rev Hematol. 2018;11(5):437‐448. doi:10.1080/17474086.2018.1452612

4. Sharda A, Flaumenhaft R. The life cycle of platelet granules. F1000Res. 2018;7:236. Published 2018 Feb 28. doi:10.12688/f1000research.13283.1

5. Andersen MS, Howard E, Lu S, Richard M, Gregory M, Ogembo G, Mazor O, Gorelik P, Shapiro NI, Sharda AV, Ghiran I. Detection of membrane-bound and soluble antigens by magnetic levitation. Lab Chip. 2017;17(20):3462‐3473. doi:10.1039/c7lc00402h

6. Felton EJ, Velasquez A, Lu S, Murphy RO, ElKhal A, Mazor O, Gorelik P, Sharda AV, Ghiran I. Detection and quantification of subtle changes in red blood cell density using a cell phone. Lab Chip. 2016;16(17):3286‐3295. doi:10.1039/c6lc00415f

7. Schulman S, Bendapudi P, Sharda A, Chen V, Bellido-Martin L, Jasuja R, Furie BC, Flaumenhaft R, Furie B. Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxid Redox Signal. 2016;24(1):1‐15. doi:10.1089/ars.2015.6530

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