Recent Publications

Flaumenhaft Lab

1. Lin L, Chen DY, Scartelli C, Xie H, Merrill-Skoloff G, Yang M, Sun L, Saeed M, Flaumenhaft R. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication. iScience. 2023 Aug 10;26(9):107602. doi: 10.1016/j.isci. 2023.107602.

2. Muse O, Patell R, Peters CG, Yang M, El-Darzi E, Schulman S, Falanga A, Marchetti M, Russo L, Zwicker JI, Flaumenhaft R. The unfolded protein response links ER stress to cancer-associated thrombosis. JCI Insight. 2023 Aug 31;8(19):e170148. doi: 10.1172/jci.insight.170148.

3. Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll KS, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R.  Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation. J Thromb Haemost. 2023 Aug;21(8):2137-2150. doi: 10.1016/j.jtha.2023.03.034. 

4. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. TMEM16E regulates endothelial cell procoagulant activity and thrombosis. J Clin Invest. 2023 Jun 1;133(11):e163808. doi: 10.1172/JCI163808.

5. Roka-Moiia Y, Ammann KR, Miller-Gutierrez S, Sheriff J, Bluestein D, Italiano JE, Flaumenhaft RC, Slepian MJ. Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function. Int J Mol Sci. 2023 Apr 17;24(8):7386. doi: 10.3390/ijms24087386.

 6. Liao X, Ji P, Chi K, Chen X, Zhou Y, Chen S, Cheng Y, Flaumenhaft R, Yuan C, Huang M. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Adv. 2023 Apr 12;13(17):11464-11471. doi: 10.1039/d3ra01135f.

7. Fritz DI, Ding Y, Merrill-Skoloff GFlaumenhaft R, Hanada T, Chishti AH.  Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets. Mol Cell Biol. 2023;43(6):283-299. doi: 10.1080/10985549.2023.2210033.

 

Bauer Lab

1. Rezende SM, Bauer KA, Zakai NA. Thromboprophylaxis in hospitalized and nonhospitalized medical patients: what’s new? Blood Adv. 2023 Sep 26;7(18):5199-5201. doi: 10.1182/bloodadvances.2023010067.

2. Ryu JH, Bauer KA, Schulman S. Periprocedural management of type 2N von Willebrand disease with efanesoctocog alfa. J Thromb Haemost. 2023 Sep 20:S1538-7836(23)00708-0. doi: 10.1016/j.jtha.2023.09.009.

3. Liu J, Elsamadisi P, Philips E, Bauer KA, Eche IM. Four-factor prothrombin complex concentrate plus andexanet alfa for reversal of factor Xa inhibitor-associated bleeding: Case series. Am J Health Syst Pharm. 2022 Aug 5;79(16):1323-1329. doi: 10.1093/ajhp/zxac079.

4. Hsu CM, Gupta S, Tighiouart H, Goyal N, Faugno AJ, Tariq A, Raichoudhury R, Sharma JH, Meyer L, Kshirsagar RK, Jose A, Leaf DE, Weiner DE; STOP-COVID Investigators.  Kidney Recovery and Death in Critically Ill Patients With COVID-19-Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study. Am J Kidney Dis. 2022 Mar;79(3):404-416.e1. doi: 10.1053/j.ajkd.2021.11.004.

5. Sharda AV, Fatovic K, Bauer KA.  Aspirin thromboprophylaxis in joint replacement surgery. Res Pract Thromb Haemost. 2022 Jan 24;6(1):e12649. doi: 10.1002/rth2.12649.

6. Zhu VW, Zhao JJ, Gao Y, Syn NL, Zhang SS, Ou SI, Bauer KA, Nagasaka M.  Thromboembolism in ALK+ and ROS1+ NSCLC patients: A systematic review and meta-analysis. Lung Cancer. 2021 Jul;157:147-155. doi: 10.1016/j.lungcan.2021.05.019.

7. Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE; STOP-COVID Investigators. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Ann Intern Med. 2021 May;174(5):622-632. doi: 10.7326/M20-6739. 

Bendapudi Lab

1. Martino J, Liu Q, Vukojevic K, Ke J, Lim TY, Khan A, Gupta Y, Perez A, Yan Z, Milo-Rasouly H, Vena N, Lippa N, Giordano JL, Saraga M, Saraga-Babic M, Westland R, Bodria M, Piaggio G, Bendapudi PK, Iglesias AD, Wapner RJ, Tasic V, Wang F, Ionita-Laza I, Ghiggeri GM, Kiryluk K, Sampogna RV, Mendelsohn CL, D’Agati VD, Gharavi AG, Sanna-Cherchi S. Mouse and human studies support DSTYK loss of function as a low penetrance and variable expressivity risk factor for congenital urinary tract anomalies. Genet Med. 2023 Sep 21:100983. doi: 10.1016/j.gim.2023.100983. 

2. Grover SP, Mackman N, Bendapudi PK. Heat shock protein 47 and venous thrombosis: letting sleeping bears lie. J Thromb Haemost. 2023 Oct;21(10):2648-2652. doi: 10.1016/j.jtha.2023.07.003. 

3. Foy BH, Stefely JA, Bendapudi PK, Hasserjian RP, Al-Samkari H, Louissaint A, Fitzpatrick MJ, Hutchison B, Mow C, Collins J, Patel HR, Patel CH, Patel N, Ho SN, Kaufman RM, Dzik WH, Higgins JM, Makar RS.  Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight. Blood Adv. 2023 Aug 22;7(16):4621-4630. doi: 10.1182/bloodadvances.2022008967.

4. Zhang Z, Hong W, Wu Q, Tsavachidis S, Li JR, Amos CI, Cheng C, Sartain SE, Afshar-Kharghan V, Dong JF, Bhatraju P, Martin PJ, Makar RS, Bendapudi PK, Li A.  Pathway-driven rare germline variants associated with transplant-associated thrombotic microangiopathy (TA-TMA). Thromb Res. 2023 May;225:39-46. doi: 10.1016/j.thromres.2023.03.001.

5. Grover SP, Kawano T, Wan J, Tanratana P, Polai Z, Shim YJ, Snir O, Brækkan S, Dhrolia S, Kasthuri RR, Bendapudi PK, McCrae KR, Wolberg AS, Hansen JB, Farkas H, Mackman N. C1 inhibitor deficiency enhances contact pathway-mediated activation of coagulation and venous thrombosis. Blood. 2023 May 11;141(19):2390-2401. doi: 10.1182/blood.2022018849.

6. Goshua G, Bendapudi PK. Evidence-Based Minireview: Should caplacizumab be used routinely in unselected patients with immune thrombotic thrombocytopenic purpura?  Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):491-494. doi: 10.1182/hematology.2022000412.

7. Goshua G, Bendapudi PK, Lee AI. Thrombosis questions from the inpatient wards. Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):481-490. doi: 10.1182/hematology.2022000384.

Schulman Lab

1. Ryu JH, Bauer KA, Schulman S. Periprocedural management of type 2N von Willebrand disease with efanesoctocog alfa.  Thromb Haemost. 2023 Sep 20:S1538-7836(23)00708-0. doi: 10.1016/j.jtha.2023.09.009. 

2. Muse O, Patell R, Peters CG, Yang M, El-Darzi E, Schulman S, Falanga A, Marchetti M, Russo L, Zwicker JI, Flaumenhaft R. The unfolded protein response links ER stress to cancer-associated thrombosis. JCI Insight. 2023 Aug 31;8(19):e170148. doi: 10.1172/jci.insight.170148.

3. Park JK, Brake MA, Schulman S. Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease. Semin Thromb Hemost. 2023 May 18. doi: 10.1055/s-0043-1769079.

4. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. TMEM16E regulates endothelial cell procoagulant activity and thrombosis. J Clin Invest. 2023 Mar 23:e163808. doi: 10.1172/JCI163808. Epub ahead of print.

5. Schulman S. How the tissue factor-VIIa complex keeps two substrates in the loop. J Thromb Haemost. 2021;19(1):52-54. doi: 10.1111/jth.15148.

6. Schulman S, El-Darzi E, Florido MH, Friesen M, Merrill-Skoloff G, Brake MA, Schuster CR, Lin L, Westrick RJ, Cowan CA, Flaumenhaft R, NIHR BioResource, Ouwehand WH, Peerlinck K, Freson K, Turro E, Furie B. A coagulation defect arising from heterozygous premature termination of tissue factor. J Clin Invest. 2020;130(10):5302-5312. doi:10.1172/JCI133780

7. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018 Apr 2;128(4):1471-1484. doi: 10.1172/JCI97488.

 

Schmaier Lab

1. Ferro EG, Kramer DB, Li S, Locke AH, Misra S, Schmaier AA, Carroll BJ, Song Y, D’Avila AA, Yeh RW, Zimetbaum PJ, Secemsky EA. Incidence, Treatment, and Outcomes of Symptomatic Device Lead-Related Venous Obstruction. J Am Coll Cardiol. 2023 Jun 20;81(24):2328-2340. doi: 10.1016/j.jacc.2023.04.017.

2. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. TMEM16E regulates endothelial cell procoagulant activity and thrombosis. J Clin Invest. 2023 Jun 1;133(11):e163808. doi: 10.1172/JCI163808.

3. Rizzo SM, Tavakol S, Bi WL, Li S, Secemsky EA, Campia U, Piazza G, Goldhaber SZ, Schmaier AA. Meningioma resection and venous thromboembolism incidence, management, and outcomes. Res Pract Thromb Haemost. 2023 Mar 15;7(2):100121. doi: 10.1016/j.rpth.2023.100121.

4. Flaumenhaft R, Enjyoji KSchmaier AA. Vasculopathy in COVID-19. Blood. 2022 Jul 21;140(3):222-235. doi: 10.1182/blood.2021012250.

5. Katz DH, Tahir UA, Bick AG, Pampana A, Ngo D, Benson MD, Yu Z, Robbins JM, Chen ZZ, Cruz DE, Deng S, Farrell L, Sinha S, Schmaier AA, Shen D, Gao Y, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Ida Chen YD, Manichaikul AW, Jain D, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Natarajan P, Gerszten RE; National Heart, Lung, and Blood Institute TOPMed (Trans-Omics for Precision Medicine) Consortium†.Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Circulation. 2022 Feb;145(5):357-370. doi: 10.1161/CIRCULATIONAHA.121.055117.

6. Raines NH, Cheung MD, Wilson LS, Edberg JC, Erdmann NB, Schmaier AA, Berryhill TF, Manickas-Hill Z, Li JZ, Yu XG, Agarwal A, Barnes S, Parikh SM.  Nicotinamide Adenine Dinucleotide Biosynthetic Impairment and Urinary Metabolomic Alterations Observed in Hospitalized Adults With COVID-19-Related Acute Kidney Injury. Kidney Int Rep. 2021 Dec;6(12):3002-3013. doi: 10.1016/j.ekir.2021.09.001.

7. Pribish AM, Secemsky EA, Schmaier AA. Venous Thromboembolism for the Practicing Cardiologist. Cardiol Clin. 2021 Nov;39(4):551-566. doi: 10.1016/j.ccl.2021.06.008.

Yang Lab

1. Bendapudi PK, Nazeen S, Ryu J, Soylemez O, Robbins AK, Rouaisnel B, O’Neil JK, Pokhriyal R, Yang M, Colling M, Pasko B, Bouzinier M, Tomczak L, Collier L, Barrios DA, Ram S, Toth-Petroczy A, Krier J, Fieg E, Dzik W’, Hudspeth J, Pozdnyakova O, Nardi V, Knight J, Maas R, Sunyaev S, Losman JA. Low-frequency inherited complement receptor variants are associated with purpura fulminans. Blood. 2023 Dec 14:blood.2023021231. doi: 10.1182/blood.2023021231.

2. Lin L, Chen DY, Scartelli C, Xie H, Merrill-Skoloff GYang M, Sun L, Saeed M, Flaumenhaft R. Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication. iScience. 2023 Aug 10;26(9):107602. doi: 10.1016/j.isci.2023.107602. 

3. Muse O, Patell R, Peters CG, Yang M, El-Darzi E, Schulman S, Falanga A, Marchetti M, Russo L, Zwicker JI, Flaumenhaft R. The unfolded protein response links ER stress to cancer-associated thrombosis. JCI Insight. 2023 Aug 31;8(19):e170148. doi: 10.1172/jci.insight.170148.

4. Yang M, Smith BC. Cysteine and methionine oxidation in thrombotic disorders. Curr Opin Chem Biol. 2023 Oct;76:102350. doi: 10.1016/j.cbpa.2023.102350.

5. Vue Z, Yang M, Yang SE, Vangay P, Vue TY, Vang KB, Yang KL. Stories from Hmong in STEMM. Trends Genet. 2023 Aug;39(8):587-592. doi: 10.1016/j.tig.2023.04.007.

6. Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll KS, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R. Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation. J Thromb Haemost. 2023 Aug;21(8):2137-2150. doi: 10.1016/j.jtha.2023.03.034. 

7. Yang M. Redox stress in COVID-19: Implications for hematologic disorders. Best Pract Res Clin Haematol. 2022 Sep;35(3):101373. doi: 10.1016/j.beha.2022.101373. 

Furie Lab

1. Schulman S, El-Darzi E, Florido MH, Friesen M, Merrill-Skoloff G, Brake MA, Schuster CR, Lin L, Westrick RJ, Cowan CA, Flaumenhaft R; NIHR BioResource; Ouwehand WH, Peerlinck K, Freson K, Turro E, Furie B. A coagulation defect arising from heterozygous premature termination of tissue factor. J Clin Invest. 2020 Oct 1;130(10):5302-5312. doi: 10.1172/JCI133780.

2. Bury L, Megy K, Stephens JC, Grassi L, Greene D, Gleadall N, Althaus K, Allsup D, Bariana TK, Bonduel M, Butta NV, Collins P, Curry N, Deevi SVV, Downes K, Duarte D, Elliot K, Falcinelli E, Furie B, et al. Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants. Hum Mutat. 2020;41(1):277‐290. doi:10.1002/humu.23927

3. Eriksson O, Chiu J, Hogg PJ, Atkinson JP, Liszewski MK, Flaumenhaft R, Furie B. Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation. J Biol Chem. 2019;294(13):4878‐4888. doi:10.1074/jbc.RA118.006792

4. Eriksson O, Stopa J, Furie B. Identification of PDI Substrates by Mechanism-Based Kinetic Trapping. Methods Mol Biol. 2019;1967:165‐182. doi:10.1007/978-1-4939-9187-7_10

5. Sharda A, Furie B. Regulatory role of thiol isomerases in thrombus formation. Expert Rev Hematol. 2018;11(5):437‐448. doi:10.1080/17474086.2018.1452612

6. Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z, Yao L, Furie B, Huang Mingdong. A long-acting PAI-1 inhibitor reduces thrombus formation. Thromb Haemost. 2017;117(7):1338‐1347. doi:10.1160/TH16-11-0891

7. Stopa JD, Baker KM, Grover SP, Flaumenhaft R, Furie B. Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates. J Biol Chem. 2017;292(22):9063‐9074. doi:10.1074/jbc.M116.771832