Recent Publications
Flaumenhaft Lab
1. Chinnaraj M, Flaumenhaft R, Pozzi N. Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles. J Biol Chem. 2022. doi: 10.1016/j.jbc.2022.102217.
2. Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood. 2022. doi: 10.1182/blood.2021012250.
3. Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA. PIEZO1 mediates a mechanothrombotic pathway in diabetes. Sci Transl Med. 2022;14(626):eabk1707. doi: 10.1126/scitranslmed.abk1707.
4. Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu XG; MGH COVID-19 Collection and Processing Team, Peters KG, Flaumenhaft R, Parikh SM. Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19. JCI Insight. 2021;6(20):e151527. doi: 10.1172/jci.insight.151527.
5. Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R. The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation. Blood. 2022;139(1):104-117. doi: 10.1182/blood.2020010342.
6. Italiano JE, Bender M, Merrill-Skoloff G, Ghevaert C, Nieswandt B, Flaumenhaft R. Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes. Blood. 2021;138(20):1998-2001. doi: 10.1182/blood.2021012496.
7. Sharda AV, Bogue T, Barr A, Mendez LM, Flaumenhaft R, Zwicker JI. Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms. Clin Cancer Res. 2021;27(20):5708-5717. doi: 10.1158/1078-0432.CCR-21-1140.
Furie Lab
Bauer Lab
1. Darzi AJ, Repp AB, Spencer FA, Morsi RZ, Charide R, Etxeandia-Ikobaltzeta I, Bauer KA, et al. Risk-assessment models for VTE and bleeding in hospitalized medical patients: an overview of systematic reviews. Blood Adv. 2020;4(19):4929-4944. doi:10.1182/bloodadvances.2020002482
5. Neumann I, Izcovich A, Zhang Y, Rada G, Kahn SR, Spencer F, Rezenda S, Dentali F, Bauer K, et al. DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta-analysis that informed 2018 ASH guidelines. Blood Adv. 2020;4(7):1512‐1517. doi:10.1182/bloodadvances.2019000840
Zwicker Lab
Bendapudi Lab
Schulman Lab
1. Schmaier AA, Anderson PF, Chen SM, El-Darzi E, Aivasovsky I, Kaushik MP, Sack KD, Hartzell HC, Parikh SM, Flaumenhaft R, Schulman S. TMEM16E regulates endothelial cell procoagulant activity and thrombosis. J Clin Invest. 2023 Mar 23:e163808. doi: 10.1172/JCI163808. Epub ahead of print.
2. Schulman S. How the tissue factor-VIIa complex keeps two substrates in the loop. J Thromb Haemost. 2021;19(1):52-54. doi: 10.1111/jth.15148.
4. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018;128(4):1471‐1484. doi:10.1172/JCI97488